A Piece of Systems Biology
Metabolomics targets thousands of metabolites in cells and biological samples. From the massive volume of the data, statistical and multivariate analyses extract “Biomarkers” as key features in biological pathways and mechanisms of action. Biomarkers can provide novel insights in metabolic pathways and together with genomic, transcriptomic, and proteomic data, a complete picture or systems approach is achieved to understanding biology and disease.
The A-B-C’s of A New Discovery
Metabolomics can be achieved with a combination of three key technologies – Analytical Chemistry, Biology, and Computer science. High-performance Analytical methods need to be operated with documented SOPs and process requirements to produce high-quality, accurate, and reproducible analyses. Biologists provide research plans, sample analyses and interpretations deriving novel hypothesis based on well-validated results. An enormous amount of metabolome data will be processed by Computer programs that extract intrinsic characteristics by using statistical and pathway-based analysis.
Improving Quality of Life
Metabolomics leads to innovations in medical care by revealing novel aspects of dysregulations in our body. Novel biomarkers help the development of pharmaceutical, diagnostic and medical cares in fields such as cancer, diabetes, cardiovascular disease, immune disease, and neuroscience. The rediscoveries modifying classical theories contribute to the improvement of advanced technologies such as oncotherapy, precision medicine, and regenerative medicine. Metabolomics is providing new perspectives of uncontrolled diseases that will lead to improvements in our quality of life.
Technology for Innovations
The number of publications involving Metabolomics has increased 10-fold in the past 10 years. This field is spreading in a variety of industries including agriculture, food science, bioprocessing, fermentation and more. Now, metabolomics is used all over the world and provided by academic and business laboratories. Over the past 10 years, we have supported many diverse organizations looking for innovative ways to achieve their goals in product quality, research, and development.
Metabolomics is a growing field. Human Metabolome Technologies (HMT) has been a leader in this field for over 20 years through our unique use of capillary electrophoresis mass spectrometry (CE-MS) and UPLC combined with Fourier transform mass spectrometry (FTMS) to provide high quality comprehensive metabolite profiling of both polar and lipophilic metabolites. Combining large data sets of cells, tissues, biofluids, extracts with our collaborative approach creates a great atmosphere for success. Our scientists with 10 to 40 years’ experience in this field are there to help interpret data and provide the highest value from these studies. We at HMT provide our own pathway analysis and biological interpretations as we educate and learn in our client relationships to advance the client’s goals, as well as contribute to the advancement of the science. Check out all the applications of metabolomics and all of our platform solution. Whether from medical research, agricultural studies, cell-based analysis, food industry or cosmetics (nutraceuticals), there are applications and solutions to assist you in your goals.