At HMT we provide a collaborative atmosphere working with our clients to find solutions by utilizing the maximum potential of our current platforms and working with our clients to drive new technology development at HMT.
One of the most significant hallmarks of cancer is its dependence on high levels of glucose and an impaired respiratory capacity despite the presence of oxygen, often termed the Warburg Effect. While most cancers do rely heavily on glucose supply, recent years has shown that cancer cells maintain a high level of metabolic flexibility.
Metabolic Flux Analysis
Isotopomer analyses have become a crucial next step for researchers with steady state metabolomics data. These analyses rely on the use of heavy atom labeled substrates such as C13 glucose. With the sensitivity of the capillary electrophoresis separation, we can accurately resolve the various isotopomers of the labeled metabolites.
Metabolomics comprehensively characterizes small polar and lipid metabolites, yielding a snapshot of physiological processes that vary according to the pathological state of cells, tissues, and organs. Therefore, the use of metabolomics can help to reveal specific metabolic alterations and potential biomarkers that are associated with disease severity in patients with systemic infections.
Metabolomics as an omics is gaining traction among the basic sciences. It is becoming more and more evident that genetic changes affecting protein production and activity has a direct relationship to metabolite levels and function. Studying metabolites and their changes are providing insights that simple gene changes cannot predict. Metabolomics is the phenotypic manifestation of genetic and protein changes.
Preclinical & Clinical
Whether early-stage discovery or screening current patient populations, the need for novel discovery in medical research and healthcare is immense.
At HMT we provide a collaborative atmosphere working with our clients to find solutions by utilizing the maximum potential of our current platforms and working with our clients to drive new technology development.
Food & Nutrition
The study of what we eat and how it can benefit or harm us is not new. Metabolites, or, nutrients, have been analyzed over centuries to understand and improve the role of food in our healthcare.
The average person contains large variations in bacteria from the mouth, the skin, sweat, and in the stomach and intestines. Bacteria hold a special place in our health both as a medical benefit and a medical risk due to their interactions with their microenvironment and host.