Publications and links for all areas of our applications.

Health Care

Diabetes / Obesity

  • Identification of Metabolites Associated with Onset of CAD in Diabetic Patients Using CE-MS Analysis: A Pilot Study.
    Omori K., et al., J Atheroscler Thromb. Mar 1;26(3):233-245. 2019. PubMed ・ Journal Website
  • Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler.
    Kanemoto N., et al., Nature Communications volume 10, Article number: 2172. 2019. PubMed ・ Journal Website
  • ACC2 Deletion Enhances IMCL Reduction Along With Acetyl-CoA Metabolism and Improves Insulin Sensitivity in Male Mice.
    Takagi H., et al., Endocrinology, Volume 159, Issue 8, Pages 3007–3019. August 2018. PubMed ・ Journal Website
  • Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.
    Zhang, C-S., et al., Nature. Aug 3;548(7665):112-116. 2017. PubMed ・ Journal Website
  • Exposure of C57BL/6J mice to long photoperiod during early life stages increases body weight and alters plasma metabolomic profiles in adulthood.
    Uchiwa T., et al., Physiol Rep. Sep;4(18):e12974. 2016. PubMed ・ Journal Website
  • L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2.
    Nakatsu D., et al., Proc. Natl. Acad. Sci. U. S. A., 112:E1067-1076, 2015.   PubMed ・ Journal Website
  • Wheat Alkylresorcinols Suppress High-Fat, High-Sucrose Diet-Induced Obesity and Glucose Intolerance by Increasing Insulin Sensitivity and Cholesterol Excretion in Male Mice. Oishi K., et al., J. Nutr., 145, 199-206, 2015.   PubMed ・ Journal Website
  • Possible Contribution of Taurine to Distorted Glucagon Secretion in Intra-Islet Insulin Deficiency: A Metabolome Analysis Using a Novel α-Cell Model of Insulin-Deficient Diabetes. Bessho M., et al., PLoS One, 9:e113254, 2014.   PubMed ・ Journal Website
  • Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.
    Hirotsu Y., et al., Genes Cells, 19, 650-665, 2014.   PubMed ・ Journal Website
  • Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides.
    Watanabe C., et al., Diabetes, 61, 74-84, 2012.   PubMed ・ Journal Website

Hepatitis / Liver dysfunction

  • Lipid desaturation-associated endoplasmic reticulum stress regulates MYCN gene expression in hepatocellular carcinoma cells.
    Qin X.Y., et al., Cell Death Dis. Jan 27;11(1):66. 2020. PubMed ・ Journal Website
  • High Throughput Screening of Serum γ-Glutamyl Dipeptides for Risk Assessment of Nonalcoholic Steatohepatitis with Impaired Glutathione Salvage Pathway.
    Saoi M., et al., J Proteome Res. Jul 2;19(7):2689-2699. 2020. PubMed ・ Journal Website
  • Changes of liver metabolites following hepatectomy with ischemia reperfusion towards liver regeneration.
    Saito Y., et al., Ann Gastroenterol Surg. Jan 30;2(3):204-211. 2018. PubMed ・ Journal Website
  • Mechanisms of sleep deprivation-induced hepatic steatosis and insulin resistance in mice.
    Shigiyama F., et al., Am J Physiol Endocrinol Metab. Nov 1;315(5):E848-E858. 2018. PubMed ・ Journal Website
  • Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133.
    Hur W., et al., Sci Rep. Apr 3;7:45557. 2017. PubMed ・ Journal Website
  • Hepatocyte β-Klotho regulates lipid homeostasis but not body weight in mice.
    Kobayashi K., et al., FASEB J. Feb;30(2):849-62. 2016. PubMed ・ Journal Website
  • Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.
    Goto M., et al., Genes Cells, 20, 464-480, 2015.   PubMed ・ Journal Website
  • Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes.
    Tsujita T., et al., Mol. Cell. Biol., 34, 3800-3816, 2014.   PubMed ・ Journal Website
  • L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with upregulation of mitochondrial pathway.
    Ishikawa H., et al., PLoS One, 9:e100627, 2014.   PubMed ・ Journal Website
  • Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell.
    Kakazu E., et al., Sci. Rep., 3:3459, 2013.   PubMed ・ Journal Website
  • Serum metabolomic profile and potential biomarkers for severity of fibrosis in nonalcoholic fatty liver disease.
    Tokushige K., et al., J .Gastroenterol., 48,1392-1400, 2013.   PubMed ・ Journal Website
  • NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
    Hirotsu Y., et al., Mol. Cell Biol., 32, 2760-2770, 2012.   PubMed ・ Journal Website

Cardiovascular Disease

  • Prevention of Atherosclerosis by the Induction of Microbial Polyamine Production in the Intestinal Lumen.
    Matsumoto M., Biol Pharm Bull. 43(2):221-229. 2020. PubMed ・ Journal Website
  • Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy.
    Rajendran J., et al., EMBO Mol Med. Jan;11(1):e9456. 2019. PubMed ・ Journal Website
  • Role of smooth muscle cell p53 in pulmonary arterial hypertension.
    Wakasugi T., et al., PLoS One. Feb 26;14(2). 2019. PubMed ・ Journal Website
  • Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure.
    Tsuda M., et al., J Cachexia Sarcopenia Muscle. Oct;9(5):844-859. 2018. PubMed ・ Journal Website
  • Titin-truncating variants affect heart function in disease cohorts and the general population.
    Schafer S., et al., Nat Genet. Jan;49(1):46-53. 2017. PubMed ・ Journal Website
  • Visualization of in vivo metabolic flows reveals accelerated utilization of glucose and lactate in penumbra of ischemic heart.
    Sugiura Y., et al., Sci Rep. Sep 1;6:32361. 2016. PubMed ・ Journal Website
  • Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart.
    Kouzu H., et al., J. Mol. Cell Cardiol., 80, 136-145, 2015.   PubMed ・ Journal Website
  • Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice.
    Nakatani K., et al., Metabolism, 64, 1165-1174, 2015.   PubMed ・ Journal Website
  • Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage.
    Yamashita A., et al., PLoS One, 9:e86426, 2014.   PubMed ・ Journal Website
  • Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy.
    Maekawa K., et al., J. Mol. Cell Cardiol. 59, 76-85, 2013.   PubMed ・ Journal Website
  • Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidemia.
    Ooga T., et al., Mol. Biosyst., 7, 1217-1223, 2011.   PubMed ・ Journal Website

Stem Cell / Regenerative Medicine

  • Metabolites Interrogation in Cell Fate Decision of Cultured Human Corneal Endothelial Cells .
    Hamuro J., et al., Invest Ophthalmol Vis Sci. Feb 7;61(2):10. 2020. PubMed ・ Journal Website
  • Glycine decarboxylase regulates the maintenance and induction of pluripotency via metabolic control.
    Kang P.J., et al., Metab Eng. May;53:35-47. 2019. PubMed ・ Journal Website
  • Evaluation of the effects of ascorbic acid on metabolism of human mesenchymal stem cells.
    Fujisawa K., et al., Stem Cell Res Ther. Apr 6;9(1):93. 2018. PubMed ・ Journal Website
  • Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency.
    Sone M., et al., Cell Metab. May 2;25(5):1103-1117.e6. 2017. PubMed ・ Journal Website
  • Hypothermic temperature effects on organ survival and restoration.
    Ishikawa J., et al., Sci. Rep., 5:9563, 2015.   PubMed ・ Journal Website
  • Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells.
    Konno M., et al., Regen. Therapy, 1, 63-71, 2015.   Journal Website
  • DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway.
    Nishikawa K., et al., Nat. Med., 21, 281-287, 2015.   PubMed ・ Journal Website
  • Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process.
    Tsuno S., et al., Sci. Rep., 4:3852, 2014. PubMed ・ Journal Website
  • Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1.
    Baba T., et al., Nat. Commun., 5:3634, 2014.   PubMed ・ Journal Website
  • CCN2 as a Novel Molecule Supporting Energy Metabolism of Chondrocytes.
    Maeda-Uematsu A., et al., J. Cell Biochem., 115, 854-865, 2014.   PubMed ・ Journal Website
  • Vascularized and functional human liver from an iPSC-derived organ bud transplant.
    Takebe T., et al., Nature, 499, 481-484, 2013.   PubMed ・ Journal Website
  • Metabolomic analysis of differential changes in metabolites during ATP oscillations in chondrogenesis.
    Kwon HJ., et al., Biomed. Res. Int., 2013:213972, 2013.   PubMed ・ Journal Website
  • Synchronized ATP oscillations have a critical role in prechondrogenic condensation during chondrogenesis.
    Kwon HJ., et al., Cell Death. Dis., 3:e278, 2012.   PubMed ・ Journal Website
  • Rhythmic Nucleotide Synthesis in the Liver: Temporal Segregation of Metabolites.
    Fustin JM., et al., Cell Rep., 1, 341-349, 2012.   PubMed ・ Journal Website


  • Glycolate is a Novel Marker of Vitamin B 2 Deficiency Involved in Gut Microbe Metabolism in Mice .
    Uebanso T., et al., Nutrients. Mar 11;12(3):736. 2020. PubMedJournal Website
  • Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
    Pryor R., et al., Cell. Sep 5;178(6):1299-1312. 2019. PubMedJournal Website
  • Gut Microbiome and Plasma Microbiome-Related Metabolites in Patients With Decompensated and Compensated Heart Failure.
    Hayashi T., et al., Circ J. Dec 25;83(1):182-192. 2018. PubMedJournal Website
  • Colonic Absorption of Low-Molecular-Weight Metabolites Influenced by the Intestinal Microbiome: A Pilot Study.
    Matsumoto M., et al., PLoS One. Jan 25;12(1):e0169207. 2017. PubMedJournal Website
  • Biotic Interactions Shape the Ecological Distributions of Staphylococcus Species.
    Kastman E.K., et al., mBio. 7 (5) e01157-16. Oct 2016. PubMed Journal Website
  • Antipruritic effects of the probiotic strain LKM512 in adults with atopic dermatitis.
    Matsumoto M., et al., Ann. Allergy Asthma. Immunol., 113, 209-216, 2014.   PubMed ・ Journal Website
  • Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice.
    Kibe R., et al., Sci. Rep., 4:4548, 2014.   PubMed ・ Journal Website
  • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.
    Yoshimoto S., et al., Nature, 499, 97-101, 2013. PubMed ・ Journal Website
  • Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study.
    Matsumoto M., et al., Front Syst. Neurosci., 7:9, 2013.   PubMed ・ Journal Website
  • Impact of Intestinal Microbiota on Intestinal Luminal Metabolome.
    Matsumoto M., et al., Sci. Rep., 2:233, 2012.   PubMed ・ Journal Website

Other Diseases

  • Glycolytic metabolism of pathogenic T cells enables early detection of GvHD by 13C-MRI .
    Assmann J., et al., Blood. Aug 12;blood.2020005770. 2020. PubMed ・ Journal Website
  • Biomarkers identified by serum metabolomic analysis to predict biologic treatment response in rheumatoid arthritis patients.
    Takahashi S., et al., Rheumatology (Oxford). Dec 1;58(12):2153-2161. 2019. PubMed ・ Journal Website
  • Therapeutic Benefit of Autophagy Modulation in Pompe Disease.
    Lim J., et al., Mol Ther. Jul 5;26(7):1783-1796. 2018. PubMed ・ Journal Website
  • NAD + repletion produces no therapeutic effect in mice with respiratory chain complex III deficiency and chronic energy deprivation.
    Purhonen J., et al., FASEB J. May 21;fj201800090R. 2018. PubMed ・ Journal Website
  • Modelling urea-cycle disorder citrullinemia type 1 with disease-specific iPSCs.
    Yoshitoshi-Uebayashi E.Y., et al., Biochem Biophys Res Commun. May 6;486(3):613-619. 2017. PubMed ・ Journal Website
  • Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency.
    Ehinger J.K., et al., Nat Commun. Aug 9;7:12317. 2016. PubMed ・ Journal Website
  • Plasma and Liver Metabolic Profiles in Mice Subjected to Subchronic and Mild Social Defeat Stress.
    Goto T., et al., J. Proteome Res., 14, 1025-1032, 2015. PubMed ・ Journal Website
  • Disease modifying effect of adiponectin in model of α-synucleinopathies.
    Sekiyama K., et al., Ann. Clin. Transl. Neurol., 1, 479-489, 2014. PubMed ・ Journal Website
  • A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study.
    Koike S., et al., Transl. Psychiatry, 4:e379, 2014. PubMed ・ Journal Website
  • Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency.
    Saheki T., et al., Mol. Genet Metab., 104, 492-500, 2011. PubMed ・ Journal Website

Cancer Metabolism

  • Targeting pheochromocytoma/paraganglioma with polyamine inhibitors.
    Rai S.K., et al., Metabolism. Sep;110:154297, 2020. PubMed ・ Journal Website
  • Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion.
    Commander R., et al., Nat Commun; Mar 24;11(1):1533, 2020. PubMed ・ Journal Website
  • The Quiescent Metabolic Phenotype of Glioma Stem Cells.
    Spehalski E.I., et al., J Proteomics Bioinform. 12(6):96-103. 2019. PubMed ・ Journal Website
  • ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming.
    Mishra, P., et al., J Clin Invest. Jan 2;128(1):323-340. 2018. PubMed ・ Journal Website
  • Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.
    Kremer J.C., et al., Cell Reports; Volume 18, ISSUE 4, P991-1004, January 24, 2017. PubMed ・ Journal Website
  • PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.
    Samanta D., et al., Cancer Res; 76(15); 4430–42, 2016. PubMed ・ Journal Website
  • SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
    Kim D., et al., Nature. 520, 363-367, 2015.   PubMed ・ Journal Website
  • The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B.
    Tambe Y., et al., Mol. Carcinog., 2015.   PubMed ・ Journal Website
  • Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer.
    Hosoda F., et al., Oncogene, 34, 1196-1206, 2015.   PubMed ・ Journal Website
  • Glucose and glutamine metabolism in oral squamous cell carcinoma: insight from a quantitative metabolomic approach.
    Ogawa T., et al. Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol., 118, 218-225, 2014.   PubMed ・ Journal Website
  • Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose.
    Miwa H., et al., Oncol. Rep., 29, 2053-2057, 2013.   PubMed ・ Journal Website
  • Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry.
    Kami K., et al., Metabolomics, 9, 444-453, 2013.   PubMed ・ Journal Website

Flux Analysis

  • Comprehensive Profiling by Non-targeted Stable Isotope Tracing Capillary Electrophoresis-Mass Spectrometry: A New Tool Complementing Metabolomic Analyses of Polar Metabolites.
    Zeng J., et al., Chemistry. Apr 11;25(21):5427-5432. 2019. PubMed ・ Journal Website
  • Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.
    Kremer J.C., et al., Cell Rep. Jan 24;18(4):991-1004. 2017. PubMed ・ Journal Website
  • Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency.
    Ehinger J.K., et al., Nat Commun. Aug 9;7:12317. 2016. PubMed ・ Journal Website
  • Quantification of folate metabolism using transient metabolic flux analysis.
    Tedeschi PM., et al., Cancer Metab., 3:6, 2015.   PubMed ・ Journal Website
  • Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.
    Makinoshima H., et al., J. Biol. Chem., 290, 17495-17504, 2015.   PubMed ・ Journal Website
  • Suppression of Microbial Metabolic Pathways Inhibits the Generation of the Human Body Odor Component Diacetyl by Staphylococcus spp.
    Hara T., et al., PLoS One, 9:e111833, 2014 .  PubMed ・ Journal Website
  • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
    Mitsuishi Y., et al., Cancer Cell, 22, 66-79, 2012.   PubMed ・ Journal Website
  • Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations.
    Kami K., et al., Mitochondrion, 12, 644-653, 2014.   PubMed ・ Journal Website
  • Functional modules, structural topology, and optimal activity in metabolic networks.
    Resendis-Antonio O., et al., PLoS Comput. Biol., 8:e1002720, 2012.   PubMed ・ Journal Website
  • Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS.
    Ohashi Y., et al., Mol. Biosyst, 4, 135-147, 2008.   PubMed ・ Journal Website


  • Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior.
    Nakayama T., et al., PNAS April 28, 117 (17) 9594-9603. 2020. PubMed  ・  Journal Website
  • A metabolic profile of polyamines in parkinson disease: A promising biomarker.
    Saiki S., et al., Ann Neurol, 86: 251-263. 2019. PubMed  ・  Journal Website
  • Plasma metabolome analysis of patients with major depressive disorder .
    Kawamura N., et al., Psychiatry Clin Neurosci. May;72(5):349-361. 2018. PubMed  ・  Journal Website
  • Metabolic profile alterations in the postmortem brains of patients with schizophrenia using capillary electrophoresis-mass spectrometry.
    Fuiji T., et al., Schizophr Res. May;183:70-74. 2017. PubMed ・ Journal Website
  • Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis.
    Yoshimi M., et al., Mol Psychiatry. Nov;21(11):1504-1510. 2016. PubMed ・ Journal Website
  • Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder.
    Ogawa S., et al., Sci. Rep., 5:7796, 2015. PubMed ・ Journal Website
  • Altered Metabolites in the Plasma of Autism Spectrum Disorder: A Capillary Electrophoresis Time-of-Flight Mass Spectroscopy Study.
    Kuwabara H., et al., PLoS One, 8:e73814, 2013. PubMed ・ Journal Website

Infectious Diseases

  • Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection.
    Chan KR. et al., Nat Med., 25(8): 1218-1224. 2019. PubMed ・ Journal Website
  • Commensal-derived metabolites govern Vibrio cholerae pathogenesis in host intestine.
    You JS. et al., Microbiome., 7(1): 132. 2019. PubMed ・ Journal Website
  • Mycoplasma infection and hypoxia initiate succinate accumulation and release in the VM-M3 cancer cells.
    Flores RE. et al.,Biochim Biophys Acta Bioenerg., 1859(9): 975-983. 2018. PubMed ・ Journal Website
  • Prevalence of Slow-Growth Vancomycin Nonsusceptibility in Methicillin-Resistant Staphylococcus aureus.
    Katayama Y. et al., Antimicrob Agents Chemother., 61(11): e00452-17. 2017. PubMed ・ Journal Website
  • Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs.
    Cohen J., et al., Front Aging Neurosci. Aug 29;9:281. 2017. PubMed ・ Journal Website
  • Profiling of Intracellular Metabolites: An Approach to Understanding the Characteristic Physiology of Mycobacterium leprae.
    Miyamoto Y., et al., PLoS Negl Trop Dis. Aug 1;10(8):e0004881. 2016. PubMed ・ Journal Website
  • Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.
    Sugiyama K. et al., PLoS One., 9(4): e94460. 2014. PubMed ・ Journal Website

Food and Nutrition

Food Science

  • Gas Chromatography–Mass Spectrometry-Based Metabolomic Analysis of Wagyu and Holstein Beef.
    Yamada T., et al., Metabolites. Mar 6;10(3):95. 2020. PubMed ・ Journal Website
  • Metabolomic analysis of SMP30/GNL knockout mice treated with fermented vegetable and fruit extract (OM-X®).
    Wakame K., et al., Functional Foods in Health and Disease, Vol 10 No 3. 2020. Journal Website
  • Dietary Supplementation with Lysine and Threonine Modulates the Performance and Plasma Metabolites of Broiler Chicken.
    Ishii T., et al., J Poult Sci. Jul 25;56(3):204-211. 2019. PubMed ・ Journal Website
  • Thiamine accumulation and thiamine triphosphate decline occur in parallel with ATP exhaustion during postmortem aging of pork muscles.
    Muroya S., et al., Meat Sci. Mar;137:228-234. 2018. PubMed ・ Journal Website
  • Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs.
    Osaki T., et al., Mar. Drugs, 13, 5007-5015, 2015.   PubMed ・ Journal Website
  • Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency.
    Ohtoyo M., et al., Mol. Cell Biochem., 400, 125-133, 2015.   PubMed ・ Journal Website
  • Regulation of free glutamate content in meat by dietary lysine in broilers.
    Watanabe G., et al., Anim. Sci. J., 86, 435-442, 2015.   PubMed ・ Journal Website
  • Multi-faceted integrated omics analysis revealed parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice.
    Jia H., et al., J. Func. Food, 11, 438–448, 2014.   Journal Website
  • An Integrated Multi-Omics Study Revealed Metabolic Alterations Underlying the Effects of Coffee Consumption.
    Takahashi S., et al., PLoS One, 9:e91134, 2014.   PubMed ・ Journal Website
  • CE-TOF MS-based metabolomic profiling revealed characteristic metabolic pathways in postmortem porcine fast and slow type muscles.
    Muroya S., et al., Meat Sci., 98, 726-735, 2014.   PubMed ・ Journal Website
  • Metabolomic analyses of blood plasma after oral administration of D-glucosamine hydrochloride to dogs.
    Osaki T., et al., Mar. Drugs, 10, 1873-1882, 2012.   PubMed ・ Journal Website
  • Metabolomics analysis of Cistus monspeliensis leaf extract on energy metabolism activation in human intestinal cells.
    Shimoda Y., et al., J. Biomed. Biotechnol., 2012:428514, 2012.   PubMed ・ Journal Website
  • Characterization of volatile and non-volatile metabolites in etiolated leaves of tea (Camellia sinensis) plants in the dark.
    Yang Z., et al., Food Chem., 135, 2268-2276, 2012.   PubMed ・ Journal Website


  • Metabolic diversification of nitrogen‐containing metabolites by the expression of a heterologous lysine decarboxylase gene in Arabidopsis.
    Shimizu Y., et al., Plant J. Nov;100(3):505-521. 2019. PubMed ・ Journal Website
  • Dietary Probiotic Effect of Lactococcus lactis WFLU12 on Low-Molecular-Weight Metabolites and Growth of Olive Flounder (Paralichythys olivaceus).
    Nguyen T.L., et al., Front Microbiol. Sep 5;9:2059. 2018. PubMed ・ Journal Website
  • Ginseng berry improves hyperglycemia by downregulating hepatic gluconeogenesis and steatosis in mice with diet-induced type 2 diabetes.
    Kim M-S., et al., Journal of Functional Foods. 35:295-302. 2017. Journal Website
  • Regulation of Primary Metabolic Pathways in Oyster Mushroom Mycelia Induced by Blue Light Stimulation: Accumulation of Shikimic Acid.
    Kojima M., et al., Sci. Rep., 5:8630, 2015.   PubMed ・ Journal Website
  • Study of polar metabolites in tobacco from different geographical origins by using capillary electrophoresis–mass spectrometry.
    Zhao J., et al., Metabolomics, 10, 805-815, 2014.   Journal Website
  • Hormones, polyamines, and cell wall metabolism during oil palm fruit mesocarp development and ripening.
    Teh HF., et al., J. Agric. Food Chem., 62, 8143-8152, 2014.   PubMed ・ Journal Website
  • Profiling of Metabolites in Oil Palm Mesocarp at Different Stages of Oil Biosynthesis.
    Neoh BK., et al., J. Agric. Food Chem., 61, 1920-1927, 2013.   PubMed ・ Journal Website
  • Differential Metabolite Profiles during Fruit Development in High-Yielding Oil Palm Mesocarp.
    Teh HF., et al., PLoS One, 8:e61344, 2013.   PubMed ・ Journal Website
  • Autophagy contributes to night-time energy availability for growth in Arabidopsis.
    Izumi M., et al., Plant Physiol., 161, 1682-1693, 2013.   PubMed ・ Journal Website
  • Deficiency of autophagy leads to significant changes of metabolic profiles in Arabidopsis.
    Izumi M., et al., Plant Signal Behav., 8:e25023, 2013.   PubMed ・ Journal Website
  • Metabolome analysis of photosynthesis and the related primary metabolites in the leaves of transgenic rice plants with increased or decreased Rubisco content.
    Suzuki Y., et al., Plant Cell Environ., 35, 1369-1379, 2012.   PubMed ・ Journal Website

Industry / Fermentation

  • Diurnal biomarkers reveal key photosynthetic genes associated with increased oil palm yield.
    Neoh B.K., et al, PLoS One. Mar 11;14(3). 2019. PubMed ・ Journal Website
  • Accumulation of intracellular S-adenosylmethionine increases the fermentation rate of bottom-fermenting brewer’s yeast during high-gravity brewing.
    Oomuro M., et al., J Biosci Bioeng. Dec;126(6):736-741. 2018. PubMed ・ Journal Website
  • Characterization of oil-producing yeast Lipomyces starkeyi on glycerol carbon source based on metabolomics and 13C-labeling.
    Maruyama Y., et al., Applied Microbiology and Biotechnology volume 102, pages8909–8920. 2018. PubMed ・ Journal Website
  • Adenine Addition Restores Cell Viability and Butanol Production in Clostridium saccharoperbutylacetonicum N1-4 (ATCC 13564) Cultivated at 37°C.
    Kiyoshi K., et al., Appl Environ Microbiol. Mar 17;83(7):e02960-16. 2017. PubMed ・ Journal Website
  • Metabolome analysis of milk fermented by γ-aminobutyric acid–producing Lactococcus lactis.
    Hagi T., et al., J Dairy Sci. Feb;99(2):994-1001. 2016. PubMed ・ Journal Website
  • Bacterial pyruvate production from alginate, a promising carbon source from marine brown macroalgae.
    Kawai S., et al., J. Biosci. Bioeng., 117, 269-274, 2014.   PubMed ・ Journal Website
  • Fermentation of Xylose Causes Inefficient Metabolic State Due to Carbon/Energy Starvation and Reduced Glycolytic Flux in Recombinant Industrial Saccharomyces cerevisiae.
    Matsushika A., et al., PLoS One, 8:e69005, 2013.   PubMed ・ Journal Website
  • Metabolic and morphological changes of an oil accumulating trebouxiophycean alga in nitrogen-deficient conditions.
    Ito T., et al., Metabolomics, 9, 178-187, 2013.   PubMed ・ Journal Website
  • Bioethanol production from marine biomass alginate by metabolically engineered bacteria.
    Takeda H., et al., Energy Environ. Sci., 4, 2575-2581, 2011.   Journal Website


  • Metabolite profiling reveals a complex response of plants to application of plant growth-promoting endophytic bacteria .
    Mahmood A., et al., Microbiol Res. Jan 25;234:126421. 2020. PubMed ・ Journal Website
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