Publications and links for all areas of our applications.

Health Care

Diabetes / Obesity

  • L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2.
    Nakatsu D., et al., Proc. Natl. Acad. Sci. U. S. A., 112:E1067-1076, 2015.   PubMed ・ Journal Website
  • Wheat Alkylresorcinols Suppress High-Fat, High-Sucrose Diet-Induced Obesity and Glucose Intolerance by Increasing Insulin Sensitivity and Cholesterol Excretion in Male Mice. Oishi K., et al., J. Nutr., 145, 199-206, 2015.   PubMed ・ Journal Website
  • Possible Contribution of Taurine to Distorted Glucagon Secretion in Intra-Islet Insulin Deficiency: A Metabolome Analysis Using a Novel α-Cell Model of Insulin-Deficient Diabetes. Bessho M., et al., PLoS One, 9:e113254, 2014.   PubMed ・ Journal Website
  • Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.
    Hirotsu Y., et al., Genes Cells, 19, 650-665, 2014.   PubMed ・ Journal Website
  • Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides.
    Watanabe C., et al., Diabetes, 61, 74-84, 2012.   PubMed ・ Journal Website

Hepatitis / Liver dysfunction

  • Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.
    Goto M., et al., Genes Cells, 20, 464-480, 2015.   PubMed ・ Journal Website
  • Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes.
    Tsujita T., et al., Mol. Cell. Biol., 34, 3800-3816, 2014.   PubMed ・ Journal Website
  • L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with upregulation of mitochondrial pathway.
    Ishikawa H., et al., PLoS One, 9:e100627, 2014.   PubMed ・ Journal Website
  • Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell.
    Kakazu E., et al., Sci. Rep., 3:3459, 2013.   PubMed ・ Journal Website
  • Serum metabolomic profile and potential biomarkers for severity of fibrosis in nonalcoholic fatty liver disease.
    Tokushige K., et al., J .Gastroenterol., 48,1392-1400, 2013.   PubMed ・ Journal Website
  • NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
    Hirotsu Y., et al., Mol. Cell Biol., 32, 2760-2770, 2012.   PubMed ・ Journal Website

Cardiovascular disease

  • Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart.
    Kouzu H., et al., J. Mol. Cell Cardiol., 80, 136-145, 2015.   PubMed ・ Journal Website
  • Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice.
    Nakatani K., et al., Metabolism, 64, 1165-1174, 2015.   PubMed ・ Journal Website
  • Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage.
    Yamashita A., et al., PLoS One, 9:e86426, 2014.   PubMed ・ Journal Website
  • Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy.
    Maekawa K., et al., J. Mol. Cell Cardiol. 59, 76-85, 2013.   PubMed ・ Journal Website
  • Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidemia.
    Ooga T., et al., Mol. Biosyst., 7, 1217-1223, 2011.   PubMed ・ Journal Website

Infection disease

  • Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.
    Sugiyama K., et al., PLoS One, 9:e94460, 2014.   PubMed ・ Journal Website
  • Erythritol alters microstructure and metabolomic profiles of biofilm composed of Streptococcus gordonii and Porphyromonas gingivalis.
    Hashino E., et al., Mol. Oral. Microbiol., 28, 435-451, 2013.   PubMed ・ Journal Website
  • Dramatic Increase in Glycerol Biosynthesis upon Oxidative Stress in the Anaerobic Protozoan Parasite Entamoeba histolytica.
    Husain A., et al., PLoS Negl. Trop. Dis., 6:e1831, 2012.   PubMed ・ Journal Website
  • Metabolomic effects of xylitol and fluoride on plaque biofilm in vivo.
    Takahashi N., et al., J. Dent. Res., 90, 1463-1468, 2011.   PubMed ・ Journal Website
  • Hepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway.
    Deng L., et al., J. Virol., 85, 8556-8568, 2011.   PubMed ・ Journal Website

Other disease

  • Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder.
    Ogawa S., et al., Sci. Rep., 5:7796, 2015.   PubMed ・ Journal Website
  • Plasma and Liver Metabolic Profiles in Mice Subjected to Subchronic and Mild Social Defeat Stress.
    Goto T., et al., J. Proteome Res., 14, 1025-1032, 2015.   PubMed ・ Journal Website
  • Disease modifying effect of adiponectin in model of α-synucleinopathies.
    Sekiyama K., et al., Ann. Clin. Transl. Neurol., 1, 479-489, 2014.   PubMed ・ Journal Website
  • A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study.
    Koike S., et al., Transl. Psychiatry, 4:e379, 2014.   PubMed ・ Journal Website
  • Altered Metabolites in the Plasma of Autism Spectrum Disorder: A Capillary Electrophoresis Time-of-Flight Mass Spectroscopy Study.
    Kuwabara H., et al., PLoS One, 8:e73814, 2013.   PubMed ・ Journal Website
  • Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency.
    Saheki T., et al., Mol. Genet Metab., 104, 492-500, 2011.   PubMed ・ Journal Website

Stem cell / Regenerative medicine

  • Hypothermic temperature effects on organ survival and restoration.
    Ishikawa J., et al., Sci. Rep., 5:9563, 2015.   PubMed ・ Journal Website
  • Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells.
    Konno M., et al., Regen. Therapy, 1, 63-71, 2015.   Journal Website
  • DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway.
    Nishikawa K., et al., Nat. Med., 21, 281-287, 2015.   PubMed ・ Journal Website
  • Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1.
    Baba T., et al., Nat. Commun., 5:3634, 2014.   PubMed ・ Journal Website
  • CCN2 as a Novel Molecule Supporting Energy Metabolism of Chondrocytes.
    Maeda-Uematsu A., et al., J. Cell Biochem., 115, 854-865, 2014.   PubMed ・ Journal Website
  • Vascularized and functional human liver from an iPSC-derived organ bud transplant.
    Takebe T., et al., Nature, 499, 481-484, 2013.   PubMed ・ Journal Website
  • Metabolomic analysis of differential changes in metabolites during ATP oscillations in chondrogenesis.
    Kwon HJ., et al., Biomed. Res. Int., 2013:213972, 2013.   PubMed ・ Journal Website
  • Synchronized ATP oscillations have a critical role in prechondrogenic condensation during chondrogenesis.
    Kwon HJ., et al., Cell Death. Dis., 3:e278, 2012.   PubMed ・ Journal Website
  • Rhythmic Nucleotide Synthesis in the Liver: Temporal Segregation of Metabolites.
    Fustin JM., et al., Cell Rep., 1, 341-349, 2012.   PubMed ・ Journal Website


  • Antipruritic effects of the probiotic strain LKM512 in adults with atopic dermatitis.
    Matsumoto M., et al., Ann. Allergy Asthma. Immunol., 113, 209-216, 2014.   PubMed ・ Journal Website
  • Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice.
    Kibe R., et al., Sci. Rep., 4:4548, 2014.   PubMed ・ Journal Website
  • Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study.
    Matsumoto M., et al., Front Syst. Neurosci., 7:9, 2013.   PubMed ・ Journal Website
  • Impact of Intestinal Microbiota on Intestinal Luminal Metabolome.
    Matsumoto M., et al., Sci. Rep., 2:233, 2012.   PubMed ・ Journal Website


  • Manual therapy ameliorates delayed‐onset muscle soreness and alters muscle metabolites in rats.
    Urakawa S., et al., Physiol. Rep., 3:e12279, 2015.   PubMed ・ Journal Website
  • Non-targeted human plasma metabolomics reveals the changes in oleoylethanolamide, a lipid-derived signaling molecule, by acute exposure of electric field.
    Nakagawa-Yagi N., et al., Integr. Mol. Med, 1, 29-37, 2014 .  Journal Website
  • Metabolomics of salivary fatigue markers in soccer players after consecutive games.
    Ra SG., et al., Appl. Physiol. Nutr. Metab., 39, 1120-1126, 2014.   PubMed ・ Journal Website
  • Effects of pH and lactate on hydrogen sulfide production by oral Veillonella spp.
    Washio J., et al., Appl. Environ Microbiol., 80, 4184-4188, 2014.   PubMed ・ Journal Website


  • Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile.
    Kuroda K., et al., Int. J. Oncol., 46, 1516-1526, 2015.   PubMed ・ Journal Website
  • Identification of Metabolic Signatures Associated with Erlotinib Resistance of Non-small Cell Lung Cancer Cells.
    Serizawa M., et al., Anticancer Res., 34, 2779-2787, 2014.   PubMed ・ Journal Website
  • CD133-positive cancer stem cells from Colo205 human colon adenocarcinoma cell line show resistance to chemotherapy and display a specific metabolomic profile.
    Vincent Z., et al., Genes Cancer, 5, 250-260, 2014.   PubMed ・ Journal Website
  • Inhibition of ATP Citrate Lyase Induces an Anticancer Effect via Reactive Oxygen Species: AMPK as a Predictive Biomarker for Therapeutic Impact.
    Migita T., et al., Am. J. Pathol., 182, 1800-1810, 2013.   PubMed ・ Journal Website
  • The effect of acyclic retinoid on the metabolomic profiles of hepatocytes and hepatocellular carcinoma cells.
    Qin XY., et al., PLoS One, 8:e82860, 2013.   PubMed ・ Journal Website
  • Metabolomic analysis revealed glycylglycine accumulation in astrocytes after methionine enkephalin administration exhibiting neuron protective effects.
    Zhao C., et al., J. Pharm. Biomed. Anal., 115, 48-54, 2015.   PubMed ・ Journal Website

Cancer Metabolism

  • SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
    Kim D., et al., Nature. 520, 363-367, 2015.   PubMed ・ Journal Website
  • Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells.
    Sakamoto A., et al., Cancer Res., 75, 1445-1456, 2015.   PubMed ・ Journal Website
  • The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B.
    Tambe Y., et al., Mol. Carcinog., 2015.   PubMed ・ Journal Website
  • Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer.
    Hosoda F., et al., Oncogene, 34, 1196-1206, 2015.   PubMed ・ Journal Website
  • Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells.
    Takebayashi S., et al., Aging Cell, 14, 689-697, 2015.   PubMed ・ Journal Website
  • Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process.
    Tsuno S., et al., Sci. Rep., 4:3852, 2014.   PubMed ・ Journal Website
  • Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Global Metabolic Pathways in EGFR-mutated Lung Adenocarcinoma.
    Makinoshima H., et al., J. Biol. Chem., 289, 20813-20823, 2014.   PubMed ・ Journal Website
  • Glucose and glutamine metabolism in oral squamous cell carcinoma: insight from a quantitative metabolomic approach.
    Ogawa T., et al. Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol., 118, 218-225, 2014.   PubMed ・ Journal Website
  • Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose.
    Miwa H., et al., Oncol. Rep., 29, 2053-2057, 2013.   PubMed ・ Journal Website
  • Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry.
    Kami K., et al., Metabolomics, 9, 444-453, 2013.   PubMed ・ Journal Website
  • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.
    Yoshimoto S., et al., Nature, 499, 97-101, 2013.   PubMed ・ Journal Website

Food and Nutrition

Food Science

  • Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs.
    Osaki T., et al., Mar. Drugs, 13, 5007-5015, 2015.   PubMed ・ Journal Website
  • Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency.
    Ohtoyo M., et al., Mol. Cell Biochem., 400, 125-133, 2015.   PubMed ・ Journal Website
  • Regulation of free glutamate content in meat by dietary lysine in broilers.
    Watanabe G., et al., Anim. Sci. J., 86, 435-442, 2015.   PubMed ・ Journal Website
  • Multi-faceted integrated omics analysis revealed parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice.
    Jia H., et al., J. Func. Food, 11, 438–448, 2014.   Journal Website
  • An Integrated Multi-Omics Study Revealed Metabolic Alterations Underlying the Effects of Coffee Consumption.
    Takahashi S., et al., PLoS One, 9:e91134, 2014.   PubMed ・ Journal Website
  • CE-TOF MS-based metabolomic profiling revealed characteristic metabolic pathways in postmortem porcine fast and slow type muscles.
    Muroya S., et al., Meat Sci., 98, 726-735, 2014.   PubMed ・ Journal Website
  • Metabolomic analyses of blood plasma after oral administration of D-glucosamine hydrochloride to dogs.
    Osaki T., et al., Mar. Drugs, 10, 1873-1882, 2012.   PubMed ・ Journal Website
  • Metabolomics analysis of Cistus monspeliensis leaf extract on energy metabolism activation in human intestinal cells.
    Shimoda Y., et al., J. Biomed. Biotechnol., 2012:428514, 2012.   PubMed ・ Journal Website
  • Characterization of volatile and non-volatile metabolites in etiolated leaves of tea (Camellia sinensis) plants in the dark.
    Yang Z., et al., Food Chem., 135, 2268-2276, 2012.   PubMed ・ Journal Website


  • Regulation of Primary Metabolic Pathways in Oyster Mushroom Mycelia Induced by Blue Light Stimulation: Accumulation of Shikimic Acid.
    Kojima M., et al., Sci. Rep., 5:8630, 2015.   PubMed ・ Journal Website
  • Study of polar metabolites in tobacco from different geographical origins by using capillary electrophoresis–mass spectrometry.
    Zhao J., et al., Metabolomics, 10, 805-815, 2014.   Journal Website
  • Hormones, polyamines, and cell wall metabolism during oil palm fruit mesocarp development and ripening.
    Teh HF., et al., J. Agric. Food Chem., 62, 8143-8152, 2014.   PubMed ・ Journal Website
  • Profiling of Metabolites in Oil Palm Mesocarp at Different Stages of Oil Biosynthesis.
    Neoh BK., et al., J. Agric. Food Chem., 61, 1920-1927, 2013.   PubMed ・ Journal Website
  • Differential Metabolite Profiles during Fruit Development in High-Yielding Oil Palm Mesocarp.
    Teh HF., et al., PLoS One, 8:e61344, 2013.   PubMed ・ Journal Website
  • Autophagy contributes to night-time energy availability for growth in Arabidopsis.
    Izumi M., et al., Plant Physiol., 161, 1682-1693, 2013.   PubMed ・ Journal Website
  • Deficiency of autophagy leads to significant changes of metabolic profiles in Arabidopsis.
    Izumi M., et al., Plant Signal Behav., 8:e25023, 2013.   PubMed ・ Journal Website
  • Metabolome analysis of photosynthesis and the related primary metabolites in the leaves of transgenic rice plants with increased or decreased Rubisco content.
    Suzuki Y., et al., Plant Cell Environ., 35, 1369-1379, 2012.   PubMed ・ Journal Website

Industry / Fermentation

  • Bacterial pyruvate production from alginate, a promising carbon source from marine brown macroalgae.
    Kawai S., et al., J. Biosci. Bioeng., 117, 269-274, 2014.   PubMed ・ Journal Website
  • Fermentation of Xylose Causes Inefficient Metabolic State Due to Carbon/Energy Starvation and Reduced Glycolytic Flux in Recombinant Industrial Saccharomyces cerevisiae.
    Matsushika A., et al., PLoS One, 8:e69005, 2013.   PubMed ・ Journal Website
  • Metabolic and morphological changes of an oil accumulating trebouxiophycean alga in nitrogen-deficient conditions.
    Ito T., et al., Metabolomics, 9, 178-187, 2013.   PubMed ・ Journal Website
  • Bioethanol production from marine biomass alginate by metabolically engineered bacteria.
    Takeda H., et al., Energy Environ. Sci., 4, 2575-2581, 2011.   Journal Website


  • Dynamic changes in the accumulation of metabolites in brackish water clam Corbicula japonica associated with alternation of salinity.
    Koyama H., et al., Comp. Biochem. Physiol. B Biochem. Mol. Biol., 181, 59-70, 2015.   PubMed ・ Journal Website
  • Arginine-ornithine Antiporter ArcD Controls Arginine Metabolism and Interspecies Biofilm Development of Streptococcus gordonii.
    Sakanaka A., et al., J. Biol. Chem., 290, 21185-21198, 2015.   PubMed ・ Journal Website
  • Physiological and genomic features of a novel sulfur-oxidizing gammaproteobacterium belonging to a previously uncultivated symbiotic lineage isolated from a hydrothermal vent.
    Nunoura T., et al., PLoS One, 9:e104959, 2014.   PubMed ・ Journal Website
  • Campylobacter jejuni pdxA affects flagellum-mediated motility to alter host colonization.
    Asakura H., et al., PLoS One, 8:e70418, 2013.   PubMed ・ Journal Website
  • Homozygous and heterozygous GH transgenesis alters fatty acid composition and content in the liver of Amago salmon (Oncorhynchus masou ishikawae).
    Sugiyama M., et al., Biol. Open, 1, 1035-1042, 2012.   PubMed ・ Journal Website
  • Cytotoxic Mechanism of Selenomethionine in Yeast.
    Kitajima T., et al., J. Biol. Chem., 287, 10032-10038, 2012.   PubMed ・ Journal Website

Flux Analysis

  • Quantification of folate metabolism using transient metabolic flux analysis.
    Tedeschi PM., et al., Cancer Metab., 3:6, 2015.   PubMed ・ Journal Website
  • Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.
    Makinoshima H., et al., J. Biol. Chem., 290, 17495-17504, 2015.   PubMed ・ Journal Website
  • Suppression of Microbial Metabolic Pathways Inhibits the Generation of the Human Body Odor Component Diacetyl by Staphylococcus spp.
    Hara T., et al., PLoS One, 9:e111833, 2014 .  PubMed ・ Journal Website
  • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
    Mitsuishi Y., et al., Cancer Cell, 22, 66-79, 2012.   PubMed ・ Journal Website
  • Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations.
    Kami K., et al., Mitochondrion, 12, 644-653, 2014.   PubMed ・ Journal Website
  • Functional modules, structural topology, and optimal activity in metabolic networks.
    Resendis-Antonio O., et al., PLoS Comput. Biol., 8:e1002720, 2012.   PubMed ・ Journal Website
  • Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS.
    Ohashi Y., et al., Mol. Biosyst, 4, 135-147, 2008.   PubMed ・ Journal Website

Infectious Diseases

  • Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection.
    Chan KR. et al., Nat Med., 2019. 25(8): 1218-1224 PubMed ・ Journal Website
  • Commensal-derived metabolites govern Vibrio cholerae pathogenesis in host intestine.
    You JS. et al., Microbiome., 2019. 7(1): 132 PubMed ・ Journal Website
  • ACC1 determines memory potential of individual CD4+ T cells by regulating de novo fatty acid biosynthesis.
    Endo Y. et al., Nat Metab., 2019. 1: 261-275  ・  Journal Website
  • Mycoplasma infection and hypoxia initiate succinate accumulation and release in the VM-M3 cancer cells.
    Flores RE. et al.,Biochim Biophys Acta Bioenerg., 2018. 1859(9): 975-983 PubMed ・ Journal Website
  • Prevalence of Slow-Growth Vancomycin Nonsusceptibility in Methicillin-Resistant Staphylococcus aureus.
    Katayama Y. et al., Antimicrob Agents Chemother., 2017. 61(11): e00452-17 PubMed ・ Journal Website
  • Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.
    Sugiyama K. et al., PLoS One., 2014. 9(4): e94460 PubMed ・ Journal Website
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